Perioperative medicine & outcomes
Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study
Authors' conclusion
The construction of a new PONV prediction score including genetic information was not possible due to limited association of the CHRM3 and KCNB2 SNPs. However, the DRD2 GA and AA genotypes (rs1800497) were associated with PONV
Study context
- Population
- Patients undergoing anaesthesia, Germany
- Exposure
- DRD2 rs1800497 GA/AA vs GG genotype
- Outcome
- Development of a new PONV prediction score including genetic information of CHRM3 and KCNB2 SNPs
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
New PONV prediction score including genetic information
- Could not be established, due to limited association of the KCNB2 and CHRM3 single nucleotide polymorphisms (SNPs) with postoperative nausea and vomiting (PONV)
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| PONV by DRD2 rs1800497 genotype · 24 h postoperativelyGA/AA vs GG | 1.5 (1.06–2.01) | P = 0.02 | |
| PONV by DRD2 rs1800497 genotype · 24 h postoperativelyGA/AA vs GG · independent of Apfel score, multivariate logistic regression | 1.4 (1.03–1.90) | P = 0.03 | |
| 0.512Relative risk (log scale) |
Original publication
Association of the dopamine D2 receptor gene SNP rs1800497 with postoperative nausea and vomiting: A prospective cohort study. Eur J Anaesthesiol Intensive Care. Published 29 July 2024. doi:10.
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