Association of timing of vasopressin initiation with renal replacement therapy in septic shock patients
Main finding · Incident RRT after T1Result — go to the resultHazard ratio 1.16 95% CI 0.76–1.75Authors' conclusion
Within the temporal definitions used in this retrospective analysis, we did not find that earlier vasopressin initiation was associated with a lower incidence of RRT as compared to later vasopressin initiation, though we did find that earlier initiation of vasopressin was associated with lower volume administration and earlier shock reversal.
Study context
- Population
- Patients with septic shock at an academic tertiary centre
- Participants
- 674 patients
- Exposure
- Early vs late vasopressin initiation after septic shock onset
- Earlyn = 327reference
- Outcome
- Time to incident renal replacement therapy (RRT)
- Follow-up
- 7 days following T1 (24 h post-shock)
Methodological detailssingle-centre, historical cohort, multivariable Cox proportional hazards regression
- Single-centre
- Historical cohort
- Multivariable Cox proportional hazards regression
Main finding
Incident RRT after T1 · 7 days
Hazard ratio
1.16
95% CI 0.76–1.75
P = 0.49
Late vs Early
HR 1.16 (95% CI 0.76–1.75); P = 0.49
As reported in the abstract
Observational data: associations, not effects.
Further findings
Shock reversal within 24 h of T0
P < 0.001
Mortality and need for mechanical ventilation
- No significant differences between groups
Original publication
Association of timing of vasopressin initiation with renal replacement therapy in septic shock patients. J Crit Care. Published 19 August 2026. doi:10.
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