Perioperative medicine & outcomes
Association of preoperative coronavirus disease 2019 with mortality, respiratory morbidity and extrapulmonary complications after elective, noncardiac surgery: An observational cohort study
Main finding · 30-day postoperative mortalityResult — go to the resultAdjusted odds ratio 0.40 95% CI 0.13–1.28Authors' conclusion
Preoperative COVID-19 or timing of surgery relative to diagnosis did not confer any added risk of 30-day postoperative mortality, PPCs, MINS or AKI. However, recent COVID-19 increased the risk of POD.
Study context
- Population
- Adults (≥ 18 years) undergoing elective noncardiac surgery under GA, tertiary teaching hospital in Shanghai, China, January–March 2023
- Participants
- 2,907 adults
- Exposure
- Preoperative COVID-19 vs no preoperative COVID-19
- Outcome
- Postoperative mortality
- Follow-up
- 30 days
Methodological detailssingle-centre, multivariable logistic regression
- Single-centre
- Multivariable logistic regression
Main finding
30-day postoperative mortality
Adjusted odds ratio
0.40
95% CI 0.13–1.28
P = 0.123
COVID-19 vs No COVID-19
aOR 0.40 (95% CI 0.13–1.28); P = 0.123
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| PPCs | 0.99 (0.71–1.38) | P = 0.944 | |
| MINS | 0.54 (0.22–1.30) | P = 0.168 | |
| AKI | 0.34 (0.10–1.09) | P = 0.070 | |
| 0.10.31310Adjusted odds ratio (log scale) |
Postoperative delirium (POD) (surgery within 7 weeks after COVID-19)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Surgery within 7 weeks after COVID-19 | 2.26 (1.05–4.86) | P = 0.036 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Postoperative sleep quality
- Not affected by preoperative COVID-19
Original publication
Association of preoperative coronavirus disease 2019 with mortality, respiratory morbidity and extrapulmonary complications after elective, noncardiac surgery: An observational cohort study. J Clin Anesth. Published 8 April 2024. doi:10.
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