Perioperative medicine & outcomes
Association of preoperative red blood cell width and postoperative 30-day mortality in patients undergoing non-cardiac surgery: a retrospective cohort study using propensity-score matching
Main finding · 30-day postoperative mortalityResult — go to the resultOdds ratio 2.146 95% CI 1.645–2.799Authors' conclusion
According to the results of this observational, propensity score-matched cohort study, uncontrolled high RDW before surgery is associated with an increased risk of death within 30 days after surgery, that is to say, patients over the age of 18 with high preoperative RDW who undergo non-cardiac surgery have a worse postoperative prognosis than those with normal RDW.
Study context
- Population
- Patients older than 18 years undergoing non-cardiac surgery, Singapore General Hospital, 2012–2016
- Participants
- 90,785 participants
- Exposure
- High vs non-high preoperative RDW
- High RDWn = 7,807
- Non-high RDWn = 7,807reference
- Outcome
- Postoperative mortality
- Follow-up
- 30 days
Methodological detailspropensity-score matched, doubly robust estimation
- Propensity-score matched
- Doubly robust estimation
Main finding
30-day postoperative mortality · 30 days after surgery
Odds ratio
2.146
95% CI 1.645–2.799
P < 0.00001
High RDW vs Non-high RDW
OR 2.146 (95% CI 1.645–2.799); P < 0.00001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| 30-day postoperative mortality, crude model (RDW) · 30 days after surgerySignificant association between RDW and 30-day mortality · crude model | 1.877 (1.476–2.388) | P < 0.00001 | |
| 30-day postoperative mortality, propensity-score adjusted model · 30 days after surgeryHigh RDW vs Control · propensity-score adjusted model | 1.867 (1.467–2.376) | P < 0.00001 | |
| 30-day postoperative mortality, original cohort · 30 days after surgeryRisk increased by 117.0% · original cohort | 2.170 (1.754–2.683) | P < 0.00001 | |
| 30-day postoperative mortality, weighted cohort · 30 days after surgeryRisk increased by 127.7% · weighted cohort | 2.272 (2.009–2.580) | P < 0.00001 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Association of preoperative red blood cell width and postoperative 30-day mortality in patients undergoing non-cardiac surgery: a retrospective cohort study using propensity-score matching. Perioper Med (Lond). Published 3 October 2024. doi:10.
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