Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study
Authors' conclusion
We observed a decrease in number of RBC units per day of ECMO over time, but changes were not associated temporally with implementation of transfusion thresholds. A transfusion threshold of hemoglobin < 8 g/dL was associated with a lower hazard of death, but these findings are limited by study methodology.
Study context
- Population
- Medical patients with acute respiratory failure receiving venovenous extracorporeal membrane oxygenation (ECMO)
- Participants
- 229 patients
- Exposure
- No threshold vs Hemoglobin < 7 g/dL
- No thresholdn = 91
- Hemoglobin < 8 g/dLn = 48reference
- Hemoglobin < 7 g/dLn = 90
- Outcome
- Trends in RBC use (number of RBC units transfused per day of ECMO support)
Methodological detailssingle-centre, segmented regression
- Single-centre
- Segmented regression
Main finding
As reported in the abstract
RBC units transfused per day of ECMO support
No threshold
0.6
mean · SD 1.0
Hemoglobin < 8 g/dL
0.3
mean · SD 0.8
Hemoglobin < 7 g/dL
0.3
mean · SD 1.1
P < 0.001
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| Hazard of death (in-hospital)No threshold vs Hemoglobin < 8 g/dL | 2.08 (1.12–3.88) | |
| Hazard of death (in-hospital)Hemoglobin < 7 g/dL vs Hemoglobin < 8 g/dL | 1.93 (1.02–3.62) | |
| Hazard of death (in-hospital)No threshold vs Hemoglobin < 7 g/dL | 1.08 (0.69–1.69) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Original publication
Association of RBC Transfusion Thresholds and Outcomes in Medical Patients With Acute Respiratory Failure Supported With Extracorporeal Membrane Oxygenation: A Single-Center Retrospective Cohort Study. Chest. Published 8 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →