Cardiothoracic & vascular anesthesia
Association Between Individualized Versus Conventional Blood Glucose Thresholds and Acute Kidney Injury After Cardiac Surgery: A Retrospective Observational Study
Authors' conclusion
Individually defined intraoperative hyperglycemia better predicted postcardiac surgery AKI than universally defined hyperglycemia. Intraoperative hyperglycemia was significantly associated with the risk of AKI only for the IHT.
Study context
- Population
- Adults undergoing cardiac surgery, single-centre tertiary teaching hospital, January 2012 to November 2021analysed
- Participants
- 2,427 adults
- Exposure
- Individualized vs conventional intraoperative hyperglycaemic thresholds
- Outcome
- Discrimination for AKI (C-statistic) of intraoperative hyperglycaemia metrics
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Individualized hyperglycemic threshold (IHT)
0.58-0.59
C-statistic
Conventional hyperglycemic threshold (CHT)
0.54
C-statistic
All p < 0.001
Observational data: associations, not effects.
Further findings
Association of IHT-defined metrics with acute kidney injury (AKI) (logistic regression)
| aOR (95% CI) | ||
|---|---|---|
| Duration of hyperglycemia (IHT) | 1.09 (1.02–1.16) | |
| Area above the IHT | 1.003 (1.001–1.004) | |
| 0.512Adjusted odds ratio (log scale) |
AKI incidence (all patients)
- Patients developing AKI
- 823 (33.9%)
Association of IHT-defined metrics with AKI (logistic regression)
- Any hyperglycemic episode (IHT) not significantly associated with AKI
Association of CHT-defined metrics with AKI
- None of the CHT-defined metrics significantly associated with AKI
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →