Cardiothoracic & vascular anesthesia
Two-Lung Ventilation Attenuates Systemic Inflammatory and Oxidative Stress Responses During Thoracic Surgery: A Randomized Clinical Trial
Authors' conclusion
Although TLV did not modify local IL-6 concentrations, it consistently dampened systemic inflammatory and oxidative activation induced by thoracic surgery
Study context
- Population
- Adults (≥18 years) undergoing thoracic surgery, general hospital in Southern Brazil, July–November 2023
- Participants
- 40 adults
- Comparison
- Two-lung ventilation (TLV) vs one-lung ventilation (OLV) during thoracic surgery
- Primary endpoint
- BAL fluid IL-6
Methodological detailsopen-label
- Open-label
Primary result
As reported in the abstract
- Bronchoalveolar lavage (BAL) fluid cytokine levels, incl. IL-6, did not differ between groups
- TLV vs OLV: P = 0.57
- Generalized mixed-effects models adjusted for age, sex, surgical duration
Further findings
| Outcome | P value |
|---|---|
| Postoperative IL-1β, operated lung | P = 0.04 |
| Oxidative damage, operated lung · postoperative | P = 0.02 |
Postoperative IL-1β, operated lung
- Reduced with TLV
Oxidative damage, operated lung · postoperative
- Reduced with TLV
Systemic inflammatory and oxidative responses
- TLV markedly attenuated: lower circulating cytokines and oxidative stress markers, significant group-by-time interactions for multiple mediators
Original publication
Two-Lung Ventilation Attenuates Systemic Inflammatory and Oxidative Stress Responses During Thoracic Surgery: A Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 24 April 2026. doi:10.
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