Cardiothoracic & vascular anesthesia
Comparative effects of flow- versus volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in thoracic surgery: A randomised controlled clinical trial
Primary resultResult — go to the resultMean difference −1.2 95% CI −8.2 to 5.7Authors' conclusion
Compared with VCV in thoracic surgery patients, FCV did not improve oxygenation or respiratory system mechanics during OLV, nor was it associated with improved outcomes.
Study context
- Population
- Thoracic surgery patients undergoing one-lung ventilation (OLV) for more than 30 min, university and pulmonary speciality hospital, Germany
- Participants
- 78 patients
- Comparison
- Flow-controlled ventilation (FCV) vs volume-controlled ventilation (VCV) during OLV
- FCVn = 39
- VCVn = 39reference
- Primary endpoint
- Arterial partial pressure of oxygen (PaO 2 )
- Follow-up
- 20 min after initiation of OLV
Methodological detailstwo-centre, two-arm
- Two-centre
- Two-arm
Primary result
As reported in the abstract
Mean difference
−1.2
95% CI −8.2 to 5.7
P = 0.721
By group
FCV vs VCV
mean difference −1.2 (95% CI −8.2 to 5.7); P = 0.721
Secondary outcomes
Mechanical power · 20 min after starting OLV
- Lower during FCV vs VCV
Other respiratory variables
- Did not differ at any time thereafter, except respiratory system compliance at end of surgery
Rescue manoeuvres for hypoxaemia or hypercapnia during OLV
- Did not differ between groups
Postoperative pulmonary and extrapulmonary complications; hospital-free days at day 30
- Did not differ between FCV and VCV
Original publication
Comparative effects of flow- versus volume-controlled one-lung ventilation on gas exchange and respiratory system mechanics in thoracic surgery: A randomised controlled clinical trial. Eur J Anaesthesiol. Published 6 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →