Cardiothoracic & vascular anesthesia
Flow-controlled versus pressure-controlled ventilation in thoracic surgery with one-lung ventilation – A randomized controlled trial
Primary result · PaO2/FiO2 ratioResult — go to the resultMD 39 95 % CI 1–75Authors' conclusion
In this single-center randomized controlled trial, flow-controlled ventilation improved gas exchange parameters in terms of oxygenation and carbon dioxide removal during one-lung ventilation in patients undergoing thoracic surgery and reduced the mechanical impact of artificial ventilation.
Study context
- Population
- Patients scheduled for elective thoracic surgery requiring OLV, university hospital, Austria43 in primary analysis
- Participants
- 46 patients
- Comparison
- Flow-controlled ventilation (FCV) vs pressure-controlled ventilation (PCV)
- FCVn = 21
- PCVn = 22reference
- Primary endpoint
- Oxygenation (PaO2/FiO2 ratio)
- Follow-up
- 30 min after the start of OLV
Methodological detailsprospective, non-blinded, single-centre
- Prospective
- Non-blinded
- Single-centre
Primary result
PaO2/FiO2 ratio · 30 min after start of OLV
MD
39
95 % CI 1–75
P = 0.047
By group
FCV vs PCV
MD 39 (95 % CI 1–75); P = 0.047
As reported in the abstract
Secondary outcomes
l/min
| Outcome | FCV | PCV | MD (l/min) (95 % CI) | P value | |
|---|---|---|---|---|---|
| Required minute volume for comparable mild hypercapnia during OLV | 3.0 | 4.5 | −1.3 (−1.9 to −0.8) | P < 0.001 | |
| −2−101Difference, l/min (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Flow-controlled versus pressure-controlled ventilation in thoracic surgery with one-lung ventilation – A randomized controlled trial. J Clin Anesth. Published 27 February 2025. doi:10.
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