Cardiothoracic & vascular anesthesia
Effect of permissive hypercarbia on lung oxygenation during one-lung ventilation and postoperative pulmonary complications in patients undergoing thoracic surgery: A prospective randomised controlled trial
Authors' conclusion
Permissive hypercarbia improved lung oxygenation during one-lung ventilation without increasing the risk of postoperative pulmonary complications or the length of hospital stay.
Study context
- Population
- ASA II to III patients scheduled for elective lung resection surgery; tertiary university hospital, Republic of Korea, November 2019 to December 2020262 analysed
- Participants
- 297 participants
- Comparison
- Target PaCO2 50 ± 5 or 60 ± 5 vs 40 ± 5 mmHg during OLV
- Primary endpoint
- Arterial oxygen partial pressure/fractional inspired oxygen ratio
- Follow-up
- After 60 min of one-lung ventilation
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Group 50
269.4
Group 60
262.9
Group 40
214.4
P < 0.001
Safety
PPCs
- Incidence comparable among the three groups
Original publication
Effect of permissive hypercarbia on lung oxygenation during one-lung ventilation and postoperative pulmonary complications in patients undergoing thoracic surgery: A prospective randomised controlled trial. Eur J Anaesthesiol. Published 15 July 2023. doi:10.
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