Neuroanesthesia & neurocritical care
Association of velocity-pressure loop-derived values recorded during neurosurgical procedures with postoperative organ failure biomarkers: a retrospective single-center study
Main finding · GALA and its predictive performanceResult — go to the resultAUC 0.88 CI 0.80–0.95Authors' conclusion
GALA under general anaesthesia prove more effective in detecting patients at risk of early cardiac or renal biological deterioration, compared to classical hemodynamic parameters.
Study context
- Population
- Patients programmed for neurosurgery with continuous velocity pressure (VP) loop monitoring, without hemodynamic instabilityanalysed
- Participants
- 86 patients
- Exposure
- Bio+ vs Bio-; intraoperative global afterload angle (GALA) vs mean arterial pressure (MAP) for prediction
- Bio+n = 47
- Bio-n = 39reference
- Outcome
- Prediction of early postoperative biomarker disruption by intraoperative GALA monitoring
- Follow-up
- 1 day post-surgery
Methodological detailssingle-centre, November 2018 to November 2020
- Single-centre
- November 2018 to November 2020
Main finding
GALA and its predictive performance
AUC
0.88
CI 0.80–0.95
P < 0.0001
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
Baseline characteristics
P < 0.0001
Hypertensive Bio+ 25% · Bio- 9%
Antihypertensive drugs Bio+ 31.9% · Bio- 7.7%
| Outcome | P value |
|---|---|
| Baseline characteristics | P = 0.009 |
| Baseline characteristics | P = 0.013 |
Original publication
Association of velocity-pressure loop-derived values recorded during neurosurgical procedures with postoperative organ failure biomarkers: a retrospective single-center study. Anaesth Crit Care Pain Med. Published 10 July 2024. doi:10.
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