Associations between enteral nutrition and outcomes in the SUP‐ICU trial: Results of exploratory post hoc analyses
Authors' conclusion
Enteral nutrition was associated with an increased risk of pneumonia and a reduced risk of gastrointestinal bleeding. The interaction between pantoprazole and enteral nutrition suggesting an increased risk of mortality requires further study.
Study context
- Population
- Critically ill ICU patients in the SUP-ICU trial (pantoprazole vs placebo stress ulcer prophylaxis)
- Comparison
- Enteral nutrition vs no enteral nutrition; interaction with pantoprazole vs placebo
- Primary endpoint
- Associations of enteral nutrition with clinically important GI bleeding, pneumonia and all-cause mortality
Methodological detailsexploratory post hoc analyses, extended Cox models with time-varying co-variates and competing events
- Exploratory post hoc analyses
- Extended Cox models with time-varying co-variates and competing events
Primary result
As reported in the abstract
Enteral nutrition vs No enteral nutritionEstimate (95% CI)P value
Clinically important GI bleeding
cause-specific HR 0.29(0.19–0.44)
P < 0.001Pneumonia
HR 1.44(1.14–1.82)
P = 0.003All-cause mortality
HR 0.22(0.18–0.27)
P < 0.001Further findings
All-cause mortality by pantoprazole allocation (subgroup)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Enteral nutrition, pantoprazole | 0.27 (0.21–0.35) | P < 0.001 | |
| Enteral nutrition, placebo | 0.17 (0.13–0.23) | P < 0.001 | |
| Pantoprazole, no enteral nutritionLittle effect on mortality | 0.83 (0.63–1.09) | P = 0.179 | |
| Pantoprazole, enteral nutritionMostly compatible with increased mortality | 1.27 (0.99–1.64) | P = 0.061 | |
| 0.10.31310Hazard ratio (log scale) |
- All-cause mortality by pantoprazole allocation (subgroup): interaction P: p = .024
Original publication
Associations between enteral nutrition and outcomes in the SUP‐ICU trial: Results of exploratory post hoc analyses. Acta Anaesthesiol Scand. Published 12 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →