The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial
Primary resultResult — go to the resultAdjusted mean difference 271 kcal/day 95% CI 189–354Authors' conclusion
A tailored nutrition intervention commenced in the ICU and continued until hospital discharge achieved a significant increase in energy delivery over the duration of hospitalisation for patients initially admitted to the ICU.
Study context
- Population
- Adults requiring invasive mechanical ventilation (MV) for 72–120 h in Intensive Care Unit (ICU) and receiving < 80% estimated energy requirements from enteral nutrition (EN), 22 hospitals in Australia and New Zealandmodified ITT analysis
- Participants
- 237 adults
- Comparison
- Tailored nutrition for the duration of hospitalisation vs usual care
- Tailored nutritionn = 119
- Usual caren = 118reference
- Primary endpoint
- Daily energy delivery from nutrition (kcal)
Methodological detailsphase II, multicentre, unblinded, parallel-group
- Phase II
- Multicentre
- Unblinded
- Parallel-group
Primary result
As reported in the abstract
Adjusted mean difference
271 kcal/day
95% CI 189–354
By group
Tailored nutrition vs Usual care
adjusted mean difference 271 kcal/day (95% CI 189–354)
Secondary outcomes
Intervention period
Hospital LOS, ventilator free days at day 28, total blood stream infection rate
- No differences in any secondary outcomes
Original publication
The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial. Crit Care. Published 6 January 2025. doi:10.
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