Pediatric anesthesia & critical care
Associations of Intraoperative Hypotension and Vasopressor Administration With Postoperative Acute Kidney Injury in Children Undergoing Liver Transplantation: A Retrospective Cohort Study
Authors' conclusion
IOH and vasopressor exposure were not independently associated with AKI in children undergoing LT.
Study context
- Population
- Children <18 years undergoing liver transplantation (LT), excluding preoperative end-stage renal disease144 LT cases, 22 excluded
- Participants
- 122 children
- Exposure
- Intraoperative hypotension (IOH) and vasopressor exposure vs none, for postoperative acute kidney injury (AKI)
- Outcome
- AKI (KDIGO criteria)
- Follow-up
- Within 7 postoperative days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Postoperative AKI (KDIGO) within 7 postoperative days
Mean difference, min (95% CI)P value
AKI vs No AKIcumulative duration MAP < 1 SD below age- and sex-adjusted mean
0.52(−15.03 to 16.07)
P = 0.948Adjusted odds ratio (95% CI)
Hypotensionmultivariate analysis; not associated with AKI
1.003(0.992–1.014)
Maximum epinephrinemultivariate analysis; not associated with AKI
1.003(0.994–1.012)
- Postoperative AKI
- 39%
Observational data: associations, not effects.
Further findings
Exploratory cluster analysis of hemodynamic phenotypes
- Distinct intraoperative hemodynamic phenotypes based on IOH and vasopressor use, significantly associated with some perioperative outcomes
- Exploratory
Original publication
Associations of Intraoperative Hypotension and Vasopressor Administration With Postoperative Acute Kidney Injury in Children Undergoing Liver Transplantation: A Retrospective Cohort Study. Paediatr Anaesth. Published 1 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →