Pediatric anesthesia & critical care
Fluid Overload Precedes and Masks Cryptic Kidney Injury in Pediatric Acute Respiratory Distress Syndrome
Authors' conclusion
AKI was associated with higher mortality and fewer VFDs in pediatric ARDS, irrespective of timing. FO-adjusted creatinine captures a group of patients with Cryptic AKI with outcomes approaching those who meet AKI by traditional criteria. Increases in FO, FO-adjusted creatinine, and ANGPT2 occur prior to meeting conventional AKI criteria.
Study context
- Population
- Intubated children with acute respiratory distress syndrome (ARDS), quaternary care PICU, 2011–2019
- Participants
- 720 children
- Exposure
- Acute kidney injury (AKI) and Cryptic AKI vs no AKI
- Outcome
- Conventionally defined AKI incidence and outcomes
- Follow-up
- Days 1-7 of ARDS
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Conventionally defined AKI
- 26%
Observational data: associations, not effects.
Further findings
Fluid overload (FO), FO-adjusted creatinine and ANGPT2 before AKI (Late AKI)
- Increased 1 day prior to meeting AKI criteria in the late AKI group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fluid Overload Precedes and Masks Cryptic Kidney Injury in Pediatric Acute Respiratory Distress Syndrome. Crit Care Med. Published 20 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →