Associations of dexamethasone's effect on morphine consumption after total knee arthroplasty—Subgroup analyses
Authors' conclusion
Our results from the quantile regression analyses indicate that the male sex and younger age (≤65 years) may be associated with a larger analgesic effect of dexamethasone than the effects in other types of patients. However, this is not supported by post-hoc multivariate linear regression analyses. The two types of analyses both supported a possible interaction with the type of anaesthesia.
Study context
- Population
- Patients undergoing TKA receiving paracetamol, ibuprofen and local infiltration analgesia
- Comparison
- Dexamethasone 24 mg IV once or twice vs placebo, by subgroup
- Primary endpoint
- Morphine consumption (primary outcome of DEX-2-TKA)
- Follow-up
- Within 48 h after TKA
Methodological detailspredefined subgroups, quantile regression adjusted for site, post hoc multivariate linear regression
- Predefined subgroups
- Quantile regression adjusted for site
- Post hoc multivariate linear regression
Primary result
As reported in the abstract
Interaction of subgroups with dexamethasone effect on morphine consumption (quantile regression)
- All remaining subgroup analyses showed no evidence of a difference
- DX2 vs Placebo: P = 0.02
- DX1 vs Placebo: P = 0.04
- Interaction P
Further findings
Interaction (post hoc multivariate linear regression)
- Sex interaction not significant
- P = 0.256
- Age interaction not significant
- P = 0.730
- Type of anaesthesia interaction significant
- P < 0.001
- Post hoc
Original publication
Associations of dexamethasone's effect on morphine consumption after total knee arthroplasty—Subgroup analyses. Acta Anaesthesiol Scand. Published 24 January 2024. doi:10.
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