Associations of dipeptidyl-peptidase 3 with short-term outcome in a mixed admission intensive care unit (ICU)-cohort
Authors' conclusion
In a mixed-ICU cohort, cDPP3 concentrations after start of initial treatment were independently associated with both mortality and development of AKI.
Study context
- Population
- Adult mixed-admission ICU patients
- Participants
- 650 patients
- Exposure
- cDPP3 concentrations and outcome
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
cDPP3 day 1
1.36(1.01–1.83)
P = 0.043cDPP3 day 2
1.49(1.16–1.93)
P = 0.002Observational data: associations, not effects.
Further findings
AKI
| OR (95% CI) | P value | ||
|---|---|---|---|
| cDPP3 day 1 | 1.31 (1.05–1.64) | P = 0.016 | |
| cDPP3 day 2 | 1.87 (1.51–2.34) | P < 0.001 | |
| cDPP3 day 3 | 1.49 (1.16–1.92) | P = 0.002 | |
| 0.512Odds ratio (log scale) |
- Day-2 cDPP3 remained an independent predictor of all-stage AKI in multivariate analyses incl. SOFA or APACHE-II
Original publication
Associations of dipeptidyl-peptidase 3 with short-term outcome in a mixed admission ICU-cohort. J Crit Care. Published 21 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →