Paediatric anaesthesia & critical care
Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta‐Analysis
Authors' conclusion
AKI incidence was high in neonates and liver transplant recipients and was associated with younger age and higher ASA class, although data were limited.
Study context
- Population
- Children aged < 18 years undergoing noncardiac surgery
- Participants
- 21,908 children · 27 studies
- Comparison
- Neonatal surgery vs Pediatric liver transplantation vs Mixed pediatric surgical populations
- Outcome
- Incidence of acute kidney injury (AKI) (KDIGO criteria)
- Follow-up
- Within 7 postoperative days
Methodological detailsobservational studies and clinical trials, PRISMA, Grading of Recommendations Assessment, Development and Evaluation (GRADE)
- Observational studies and clinical trials
- PRISMA
- GRADE
Pooled result
As reported in the abstract
AKI incidence
- Considerable heterogeneity limited interpretability of a single overall pooled incidence
- I2 = 98.7%
Further pooled results
| Outcome | Values | P value |
|---|---|---|
| AKI incidence by ASA class (mixed pediatric surgical populations subgroup)ASA 3 vs ASA 1-2 | ASA 1-2 2.4% · ASA 3 7.5% · ASA 4-5 18.9% | P < 0.001 |
| AKI incidence by ASA class (mixed pediatric surgical populations subgroup)ASA 4-5 vs ASA 1-2 | P < 0.001 | |
| AKI incidence by age (mixed pediatric surgical populations subgroup)12-18 years vs 0-2 years | 0-2 years 9.8% · 12-18 years 4.0% | P < 0.001 |
Original publication
Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta‐Analysis. Paediatr Anaesth. Published 18 August 2026. doi:10.
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