Perioperative medicine & outcomes

Automated Electronic Frailty Index–Identified Frailty Status and Associated Postsurgical Adverse Events

JAMA Netw OpenPublished Retrospective cohort study

Authors' conclusion

This cohort study found that frailty, as measured by an automatically calculated index integrated within the EHR, was associated with increased risk of adverse events after noncardiac surgery.

Study context

Population
Patients 55 years or older undergoing elective noncardiac surgery of at least 1 hour, Winston-Salem, North Carolina, October 2017–June 2021
Participants
33,449 patients
Exposure
Prefrail or frail vs fit status by electronic frailty index
  • Fitn = 11,563reference
  • Prefrailn = 15,928
  • Frailn = 5,958
Outcome
Composite of 8 adverse events:
  • PSI 90 score
  • Hospital-acquired conditions
  • In-hospital mortality
  • 30-day mortality
  • 30-day readmission
  • 30-day ED visit
  • Transfer to skilled nursing facility
  • Unexpected ICU admission after surgery
Methodological detailssingle-centre, tertiary care academic medical center
  • Single-centre
  • Tertiary care academic medical center

Main finding

As reported in the abstract

Adjusted for age, sex, race and ethnicity, and comorbidity burden
Each group vs fitOdds ratio (95% CI)P value
Prefrail
1.24(1.18–1.30)
P < 0.001
Frail
1.71(1.58–1.82)
P < 0.001

Observational data: associations, not effects.

Secondary outcomes

OutcomeOdds (95% CI)P value
Composite postoperative adverse events per 0.03-unit increase in eFI1.06 (1.03–1.13)P < 0.001

Original publication

Automated Electronic Frailty Index–Identified Frailty Status and Associated Postsurgical Adverse Events. JAMA Netw Open. Published 1 November 2023. doi:10.1001/jamanetworkopen.2023.41915

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