Perioperative medicine & outcomes
Influence of frailty status on the incidence of intraoperative hypotensive events in elective surgery: Hypo-Frail, a single-centre retrospective cohort study
Authors' conclusion
Prefrail and frail patients aged ≥70 yr experienced up to 16% more IOH during surgery and 28% more during anaesthesia induction compared with robust patients.
Study context
- Population
- Surgical patients ≥70 yr with preoperative frailty assessment, elective surgery
- Participants
- 2,495 patients
- Exposure
- Prefrail and frail vs robust
- Outcome
- Likelihood, rate, duration and severity of IOH (MAP <65 mm Hg)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Rate of IOH during surgery
Each group vs robustIncidence rate ratio (95% CI)P value
Prefrail
1.09(1.03–1.16)
P = 0.002Frail
1.16(1.04–1.29)
P = 0.007Observational data: associations, not effects.
Further findings
| Outcome | IRR (CI) | P value | |
|---|---|---|---|
| Rate of IOH during anaesthesia inductionPrefrail vs Robust | 1.28 (1.12–1.47) | P < 0.001 | |
| 0.512Incidence rate ratio (log scale) |
Time-weighted duration of intraoperative hypotension (IOH) during anaesthesia induction
| IRR (CI) | P value | ||
|---|---|---|---|
| Frailty status | 1.15 (1.06–1.24) | P = 0.001 | |
| 0.512Incidence rate ratio (log scale) |
- No differences in severity of IOH when surgery or induction duration taken into account
Mediator analysis
- Frailty status accounted for >90% after considering number of measured BPs and surgical duration
- Frailty status accounted for >70% after accounting for total propofol dose
Original publication
Influence of frailty status on the incidence of intraoperative hypotensive events in elective surgery: Hypo-Frail, a single-centre retrospective cohort study. Br J Anaesth. Published 24 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →