Respiratory failure & ventilation
Automatic continuous P0.1 measurements during weaning from mechanical ventilation: a clinical study
An erratum to this article was published (Ann Intensive Care, 17 Jun 2025 ↗)
Authors' conclusion
The delta of P0.1vent values between SBT and reventilation are higher for patients who fail extubation, especially for those who had ARDS. While elevated P0.1 vent values were associated with extubation failure, the overlap in values limits its usefulness as a reliable predictor.
Study context
- Population
- Adults intubated >24 h and screened for weaning from mechanical ventilation (MV); Spontaneous breathing trial (SBT) 1 h at PS0 ZEEP, then 1 h reventilation (pressure support 8–12 cmH2O, PEEP 5 cmH2O)measurements from 212 patients
- Participants
- 224 adults
- Exposure
- Extubation success vs extubation failure vs SBT failure
- Successful extubationsn = 157reference
- Extubation failuresn = 46
- SBT failuresn = 21
- Outcome
- Association of P0.1 vent values with extubation success or failure; factors influencing P0.1 vent
Methodological detailsFebruary 2022 to April 2023
- February 2022 to April 2023
Main finding
As reported in the abstract
P0.1 vent mean values
- Significantly higher for extubation failures and SBT failures vs successful extubations
- p < 0.001
- Delta P0.1 vent (reventilation vs SBT): success vs failure
- 0.21 (0.02-0.62) cm H2O vs. 1.12 (0.54-2.38) cm H2O; p < 0.0001
Observational data: associations, not effects.
Further findings
P0.1 vent, previous ARDS vs none (SBT and reventilation periods)
- Previous ARDS vs no ARDS
- 1.08 (0.70; 2.02) cmH2O vs. 0.80 (0.54; 1.28) cmH2O (p = 0.003)
P0.1 vent, airway humidification vs none
- With vs without humidification
- 0.92 (0.57; 1.54) cmH2O vs. 1.27 (0.91; 2.24) cmH2O, p = 0.003
Original publication
Automatic continuous P0.1 measurements during weaning from mechanical ventilation: a clinical study. Ann Intensive Care. Published 1 April 2025. doi:10.
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