Respiratory failure & ventilation
Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial
Primary result · Intubation and/or deathResult — go to the resultMean odds ratio 0.74 95% CrI 0.48–1.09Authors' conclusion
In this randomized clinical trial of nonintubated patients with COVID-19 and hypoxemic respiratory failure, daily APP of 6 hours showed a high probability of reduced endotracheal intubation and/or death over a wide range of prior distributions.
Study context
- Population
- Nonintubated adults requiring at least 3 L/min oxygen for COVID-19-related hypoxemic respiratory failure, wards and intensive care unit (ICUs), 20 hospitals in France and 1 in Mexico, July 2020–August 2021included in final analysis
- Participants
- 445 adults
- Comparison
- Awake prone positioning vs standard care
- Primary endpoint
- Composite of:
- Intubation
- Death
- Follow-up
- 28 days
Methodological detailsmulticentre, bayesian analysis, 1:1 randomisation
- Multicentre
- Bayesian analysis
- 1:1 randomisation
Primary result
Intubation and/or death
Mean odds ratio
0.74
95% CrI 0.48–1.09
APP vs Standard care
mean OR 0.74 (95% CrI 0.48–1.09)
As reported in the abstract
- Posterior probability that awake prone positioning (APP) decreased intubation and/or death vs standard care
- 93.8%
Secondary outcomes
| Outcome | Mean difference (days) (95% CrI) | |
|---|---|---|
| Days alive and free from mechanical ventilation · 28 daysCrI | 0.33 (−1.37 to 2.03) | |
| Days alive outside the ICU · 28 daysCrI | 1.28 (−0.78 to 3.34) | |
| Days alive outside the hospital · 28 daysCrI | 1.55 (−0.22 to 3.32) | |
| −2024Difference, days (linear scale) |
Original publication
Awake Prone Positioning in Patients With COVID-19 Respiratory Failure: A Randomized Clinical Trial. JAMA Netw Open. Published 1 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →