Pediatric anesthesia & critical care
Balanced electrolyte solution with 1% glucose as intraoperative maintenance fluid in infants: a prospective study of glucose, electrolyte, and acid–base homeostasis
Main finding · Plasma glucose concentrationResult — go to the resultMean difference 0.8 mM 95% CI 0.6–0.9Authors' conclusion
In infants undergoing surgery, maintenance infusion with a balanced electrolyte solution containing 1% glucose, at rates similar to those proposed by Holliday and Segar is a safe alternative with regards to homeostasis of glucose, electrolytes, and acid-base balance.
Study context
- Population
- Infants 1–12 months of age undergoing surgery
- Participants
- 365 infants
- Outcome
- Maintenance of normoglycaemia (plasma glucose concentration)
- Follow-up
- Induction to end of anaesthesia
Methodological detailstwo-centre, single-group
- Two-centre
- Single-group
Main finding
Plasma glucose concentration · induction vs end of anaesthesia
Mean difference
0.8 mM
95% CI 0.6–0.9
P < 0.001
End of anaesthesia vs Induction
mean difference 0.8 mM (95% CI 0.6–0.9); P < 0.001
As reported in the abstract
- Mean plasma glucose at induction (mM)
- 5.3
- Mean plasma glucose at end of anaesthesia (mM)
- 6.1
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Infusion rate of maintenance fluid | Balanced electrolyte solution with 1% glucose median 3.97 (IQR 3.21–5.35) ml kg-1 h-1 |
Sodium, chloride, ketone bodies, base excess
- Mean sodium concentration remained stable during anaesthesia
- Chloride and ketone body concentration increased and base excess decreased, but within the normal range
Safety
Hypoglycaemia (<3.0 mM)
- No cases of hypoglycaemia (<3.0 mM)
Electrolytes and acid–base · End of anaesthesia
- Mean sodium concentration stable during anaesthesia
- Chloride and ketone body concentration increased and base excess decreased, within normal range
Original publication
Balanced electrolyte solution with 1% glucose as intraoperative maintenance fluid in infants: a prospective study of glucose, electrolyte, and acid–base homeostasis. Br J Anaesth. Published 5 November 2024. doi:10.
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