Cardiothoracic & vascular anesthesia
Fibrinolytic activity in infants undergoing cardiac surgery on cardiopulmonary bypass with routine tranexamic acid: A prospective cohort substudy within the FIBrinogen CONcentrate randomised control trial
Authors' conclusion
Fibrinolysis is activated after paediatric cardiac CPB surgery as indicated by increased tPA-Ag and ROTEM ML.
Study context
- Population
- Infants (median age 6.3 months) undergoing cardiac surgery on cardiopulmonary bypass (CPB) with routine intra-operative TXA
- Participants
- 90 infants
- Comparison
- Fibrinogen concentrate vs placebo during CPB
- Fibrinogen concentraten = 60
- Placebon = 30reference
- Outcome
- Peri-operative fibrinolysis: ROTEM maximum clot lysis (ML), PAP and tPA-Ag
- Follow-up
- Pre-CPB, on-CPB, post-CPB and 4 h after PICU admission
Methodological detailsprospective cohort, nested within the FIBrinogen CONcentrate (FIBCON) randomised controlled trial, single centre
- Prospective cohort
- Nested within the FIBCON randomised controlled trial
- Single centre
Main finding
As reported in the abstract
Fibrinolytic activity
- t-PA and plasmin-antiplasmin (PAP) correlated; neither correlated with rotational thromboelastometry (ROTEM) ML
- P = 0.001
- Each 100 μg l −1 rise in PAP associated with reduction in mean early postoperative blood loss
- 7.9%
Original publication
Fibrinolytic activity in infants undergoing cardiac surgery on cardiopulmonary bypass with routine tranexamic acid: A prospective cohort substudy within the FIBrinogen CONcentrate randomised control trial. Eur J Anaesthesiol. Published 31 January 2025. doi:10.
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