Cardiothoracic & vascular anesthesia
The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses
Pooled resultResult — go to the resultOdds ratio 0.96 95% CI 0.75–1.22Authors' conclusion
This current study suggested that TXA administration did not influence renal outcomes in cardiovascular surgical patients.
Study context
- Population
- Cardiovascular surgical patients
- Participants
- 6,450 patients · 19 randomized controlled trials (RCTs)
- Comparison
- Tranexamic acid (TXA) vs placebo
- TXAn = 3,280
- Placebon = 3,170reference
- Outcome
- Incidence of postoperative acute kidney injury (AKI)
Pooled result
As reported in the abstract
Odds ratio
0.96
95% CI 0.75–1.22
P = 0.72
By group
TXA vs Placebo
OR 0.96 (95% CI 0.75–1.22); P = 0.72
Further pooled results
| Outcome | Weighted mean difference (95% CI) | P value | |
|---|---|---|---|
| Postoperative serum creatinine | 2.38 (−2.80 to 7.56) | P = 0.37 | |
| Postoperative blood urea nitrogen | −0.16 (−0.92 to 0.61) | P = 0.69 | |
| −50510Difference (linear scale) |
| Outcome | TXA | Placebo | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| 30-day postoperative mortality | 1.1% | 1.6% | 0.71 (0.46–1.09) | P = 0.12 | |
| 0.512Odds ratio (log scale) |
Original publication
The Effects of Tranexamic Acid on Renal Outcomes in Patients Undergoing Cardiovascular Surgery: A Systematic Review and Meta-Analysis Compliant With Preferred Reporting Items for Systematic Reviews and Meta-Analyses. J Cardiothorac Vasc Anesth. Published 15 November 2025. doi:10.
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