Bioequivalence and Pharmacokinetics of Intravenous Calcium during Cesarean Delivery
Primary result · Dose ratio of calcium gluconate to calcium chlorideResult — go to the resultDose ratio 3.11 95% CI 2.77–3.48Authors' conclusion
This study confirmed a 3:1 dose ratio of calcium gluconate to calcium chloride and estimated the pharmacokinetics over the first hour after intravenous delivery.
Study context
- Population
- Parturients undergoing cesarean delivery181 measurements
- Participants
- 34 participants
- Comparison
- Calcium gluconate vs Calcium chloride
- Primary endpoint
- Dose ratio of calcium gluconate to calcium chloride (venous serum ionized calcium)
Methodological detailspooled data from two recent clinical trials
- Pooled data from two recent clinical trials
Primary result
As reported in the abstract
Dose ratio of calcium gluconate to calcium chloride
Dose ratio
3.11
95% CI 2.77–3.48
Further findings
Population pharmacokinetics of IV calcium (two-compartment model; 311 measurements, 70 parturients)
- Systemic clearance, l/min
- 0.18 (95% CI 0.07 to 0.27)
- Distributional clearance, l/min
- 1.25 (95% CI 1.03 to 1.56)
- Central volume, l
- 10.9 (95% CI 9.3 to 12.6)
- Peripheral volume, l
- 16.5 (95% CI 12.5 to 24.7)
Time course after adjusting for dose ratio
- Calcium gluconate and calcium chloride had identical time courses
Serum ionized calcium after 1-g calcium chloride infusion
- Peak increase, mM (0.38 to 0.42)
- 0.39
- Time to decrease by half after infusion start, min (23 to 40)
- 29
Original publication
Bioequivalence and Pharmacokinetics of Intravenous Calcium during Cesarean Delivery. Anesthesiology. Published 3 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →