Paediatric anaesthesia & critical care
Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial
Authors' conclusion
These findings expand our understanding of the biology underlying inflammatory subphenotypes and provide biologic insight into the mortality benefit of TGC in hyperinflammatory children.
Study context
- Population
- Hyperglycemic children with heart and lung failure (HALF-PINT participants)740 blood samples
- Participants
- 293 children
- Comparison
- Hypoinflammatory vs Hyperinflammatory
- Hypoinflammatoryn = 250reference
- Hyperinflammatoryn = 43
Methodological detailsmechanistic, causal mediation analysis, plasma cytokines and whole-blood transcriptomics
- Mechanistic
- Causal mediation analysis
- Plasma cytokines and whole-blood transcriptomics
Primary result
As reported in the abstract
Biologic response to TGC by subphenotype · Study Days 0, 2, and 4
- Hyperinflammatory subphenotype: greater baseline expression of genes relating to inflammation, cell-cycle activity and immunometabolism
- Hyperinflammatory treated to 80-110 mg/dl vs 150-180 mg/dl: greater reductions in inflammatory cytokines, innate immune and heme metabolism gene expression, and increased lymphocyte gene expression
- Causal mediation: these changes partly explained the mortality benefit of tight glycemic control (TGC) in the hyperinflammatory subgroup
Original publication
Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial. Am J Respir Crit Care Med. Published 1 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →