Bispectral Index Changes Following Boluses of Commonly Used Intravenous Medications During Volatile Anesthesia Identified From Retrospective Data
Authors' conclusion
Modest, but persistent changes in BIS index occurred following doses of ketamine (increase) and midazolam (decrease) during periods of stable volatile anesthetic administration.
Study context
- Population
- Patients under volatile-based GA monitored with bispectral (BIS), academic medical center
- Participants
- 20,170 distinct cases
- Exposure
- BIS index change after single IV drug boluses during volatile-based GA
- Outcome
- Change in BIS index following drug administration
Methodological detailssingle academic medical centre, electronic anaesthesia records, novel screening approach
- Single academic medical centre
- Electronic anaesthesia records
- Novel screening approach
Main finding
As reported in the abstract
Change in BIS index
Ketamine
3.8
median · confidence limits 2.5–5.0
Midazolam
3.0
median · confidence limits 1.5–4.5
- Ketamine: increase in BIS index
- 3.8
- Midazolam: decrease in BIS index
- 3.0
Observational data: associations, not effects.
Further findings
Sensitivity analyses by volatile concentration, dose and time window · 11 to 20 minutes postadministration
- Similar BIS changes with midazolam and ketamine at different volatile concentrations and doses; changes persisted 11 to 20 minutes postadministration
Original publication
Bispectral Index Changes Following Boluses of Commonly Used Intravenous Medications During Volatile Anesthesia Identified From Retrospective Data. Anesth Analg. Published 15 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →