Perioperative medicine & outcomes
Bispectral Index–guided Anesthesia for Older Patients Having Noncardiac Surgery: A Randomized Multicenter Trial
Primary resultResult — go to the resultHazard ratio 1.02 95% CI 0.88–1.17Authors' conclusion
Hypnotic depth, as assessed by BIS, was similar in patients with or without BIS-guided anesthetic titration.
Study context
- Population
- Patients aged 65 yr or older scheduled for elective noncardiac surgery (ASA I to IV), 21 tertiary-care hospitals in China, 2015–2022
- Participants
- 6,982 patients
- Comparison
- BIS-guided vs routine anesthetic management
- BIS-guidedn = 3,485
- Routinen = 3,497reference
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 yr
Methodological detailsdouble-blind, multicentre, 1:1 randomisation
- Double-blind
- Multicentre
- 1:1 randomisation
Primary result
As reported in the abstract
Hazard ratio
1.02
95% CI 0.88–1.17
P = 0.812
Events by treatment group
BIS-guided vs Routine
HR 1.02 (95% CI 0.88–1.17); P = 0.812
Secondary outcomes
| Outcome | BIS-guided | Routine | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Complications · 30 days | 10.4% | 10.6% | 0.99 (0.85–1.16) | P = 0.938 | |
| 0.512Relative risk (log scale) |
| Outcome | BIS-guided | Routine |
|---|---|---|
| BIS valuesAveraged | 47 | 46 |
Functional independence and quality of life
- No significant differences
Original publication
Bispectral Index–guided Anesthesia for Older Patients Having Noncardiac Surgery: A Randomized Multicenter Trial. Anesthesiology. Published 25 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →