Perioperative medicine & outcomes
Cardiac index-guided therapy to maintain optimised postinduction cardiac index in high-risk patients having major open abdominal surgery: the multicentre randomised iPEGASUS trial
Primary resultResult — go to the resultOdds ratio 1.87 95% CI 1.03–3.39Authors' conclusion
Maintaining optimised postinduction cardiac index during and for the first 8 h after surgery did not reduce, and possibly increased, the incidence of a composite outcome of complications within 28 days after surgery compared with routine care in high-risk patients having elective major open abdominal surgery.
Study context
- Population
- High-risk patients having elective major open abdominal surgery, 3 German and 2 Spanish centres318 analysed
- Participants
- 380 patients
- Comparison
- Cardiac index-guided therapy vs routine care
- Cardiac index-guided therapyn = 152
- Routine caren = 166reference
- Primary endpoint
- Composite of:
- Moderate
- Severe complications
- Follow-up
- Within 28 days after surgery
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Odds ratio
1.87
95% CI 1.03–3.39
P = 0.038
Events by treatment group
Cardiac index-guided therapy vs Routine care
OR 1.87 (95% CI 1.03–3.39); P = 0.038
Further findings
- Per-protocol analyses confirmed the results of the primary outcome analysis
Original publication
Cardiac index-guided therapy to maintain optimised postinduction cardiac index in high-risk patients having major open abdominal surgery: the multicentre randomised iPEGASUS trial. Br J Anaesth. Published 26 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →