Nociception Level Index–Guided Intraoperative Analgesia for Improved Postoperative Recovery: A Randomized Trial
Primary result · Pain score, first 60 minutes after awakeningResult — go to the resultDifference in means 0.08 CI −1.43 to 1.58- stopped for futility
- Enrolled November 2020 to October 2021; stopped for futility
Authors' conclusion
More intraoperative fentanyl was given in NOL-guided patients, but NOL guidance did not reduce initial postoperative pain scores.
Study context
- Population
- Patients having major abdominal open and laparoscopic surgeriesplanned maximum 144
- Participants
- 72 patients
- Comparison
- Nociception level (NOL)-guided fentanyl vs fentanyl per clinical routine
- NOLn = 35
- Routine caren = 37reference
- Primary endpoint
- Pain score (0-10 verbal response scale) at 10-minute intervals
- Follow-up
- Initial 60 minutes of recovery
Methodological detailssingle-center
- Single-center
Primary result
Pain score, first 60 minutes after awakening
Difference in means
0.08
CI −1.43 to 1.58
P = 0.895
By group
NOL
4.12
mean · SE 0.59
Routine care
4.04
mean · SE 0.58
NOL vs Routine care
difference in means 0.08 (CI −1.43 to 1.58); P = 0.895
As reported in the abstract
Secondary outcomes
Intraoperative fentanyl
Morphine in recovery period
| Outcome | Median reduction (minutes) (95% CI) |
|---|---|
| Time with NOL index >25 | 14 (4–25) |
Original publication
Nociception Level Index–Guided Intraoperative Analgesia for Improved Postoperative Recovery: A Randomized Trial. Anesth Analg. Published 20 January 2023. doi:10.
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