Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial
Authors' conclusion
NOL®-guided opioid titration did not reduce perioperative opioid consumption or improve early postoperative outcomes compared with standard multimodal analgesia in women undergoing laparoscopic surgery for endometriosis.
Study context
- Population
- Premenopausal women undergoing laparoscopic surgery for suspected endometriosis or adenomyosisanalysed
- Participants
- 111 women
- Comparison
- NOL® vs control
- NOL®n = 54
- Controln = 57reference
- Primary endpoint
- Total perioperative opioid consumption
Methodological detailsprospective, single-blinded
- Prospective
- Single-blinded
Primary result
As reported in the abstract
Adjusted mean difference, Fentanyl
14 μg
Adjusted mean difference, Remifentanil
52 μg
Secondary outcomes
Postoperative pain scores (NRS) · all time points
- Comparable between groups at all time points
Predictors of opioid use and PACU LOS
- Surgery duration independent predictor of opioid use
- P < 0.001
- Surgery duration independent predictor of PACU LOS
- P = 0.01
- Treatment group had no significant effect
NOL®-derived metrics
- Not associated with opioid consumption or pain
Preoperative pain (Mankoski Pain Scale) (exploratory) · late PACU phase
- Higher preoperative MPS independently predicted higher pain scores
- Exploratory analysis
Original publication
Nociception-guided opioid administration within multimodal analgesia for laparoscopic endometriosis surgery: a randomized controlled trial. J Clin Monit Comput. Published 22 June 2026. doi:10.
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