Neuroanesthesia & neurocritical care
Comparison of analgesia nociception index, surgical pleth index and hemodynamic parameters between patients receiving fentanyl versus dexmedetomidine analgesia for supratentorial craniotomy - an open label active-controlled randomized trial
Authors' conclusion
ANI during use of dexmedetomidine and SPI while using fentanyl, might be the better choices as intraoperative nociception monitors.
Study context
- Population
- Patients undergoing elective supratentorial surgery under GA
- Participants
- 58 patients
- Comparison
- Fentanyl vs dexmedetomidine infusion for intraoperative analgesia
- Fentanyln = 29
- Dexmedetomidinen = 29
Methodological detailsopen label, active-controlled
- Open label
- Active-controlled
Primary result
As reported in the abstract
Maximum change in ANI, SPI, HR and MAP and response time after noxious stimuli
- Intubation: Surgical pleth index (SPI) changed more with fentanyl than dexmedetomidine (37 vs 20 units)
- p = 0.007
- Skull pinning: instantaneous and mean Analgesia Nociception Index (ANI) changed more with dexmedetomidine
- p = 0.024 and 0.009
- Skull pinning: longer ANI response time with dexmedetomidine
- p = 0.039
Original publication
Comparison of analgesia nociception index, surgical pleth index and hemodynamic parameters between patients receiving fentanyl versus dexmedetomidine analgesia for supratentorial craniotomy - an open label active-controlled randomized trial. J Clin Monit Comput. Published 31 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →