Cardiac arrest & resuscitation
Bystander CPR Technique and Outcomes for Cardiac Arrest With and Without Opioid Toxicity
Authors' conclusion
In this cohort study of OHCA, bystander CCV-CPR (compared with CC-CPR) was associated with improved outcomes in opioid-associated OHCA; however, this association was not observed among undifferentiated cardiac arrests.
Study context
- Population
- Adults with EMS-treated Out-of-hospital Cardiac Arrest (OHCA), British Columbia Cardiac Arrest Registry, December 2014–March 2020; 1343 opioid-associated (Opioid-associated OHCA (OA-OHCA)) and 9556 undifferentiated OHCAs24 ventilation-only cases removed
- Participants
- 10,923 adults
- Exposure
- Bystander CCV-CPR or no CPR vs CC-CPR, in opioid-associated and undifferentiated OHCA
- Outcome
- Favorable neurologic outcome (cerebral performance category ≤2)
- Follow-up
- Hospital discharge
Methodological detailsregistry-based, multivariable Utstein-adjusted logistic regression, complete-case analysis
- Registry-based
- Multivariable Utstein-adjusted logistic regression
- Complete-case analysis
Main finding
As reported in the abstract
Favorable neurologic outcome, by OHCA type (interaction analysis)
Each group vs CC-CPRAdjusted odds ratio (95% CI)
CCV-CPROA-OHCA
2.85(1.21–6.75)
No CPROA-OHCA
1.52(0.82–2.82)
CCV-CPRundifferentiated OHCA
1.16(0.80–1.67)
No CPRundifferentiated OHCA
0.69(0.55–0.87)
Observational data: associations, not effects.
Original publication
Bystander CPR Technique and Outcomes for Cardiac Arrest With and Without Opioid Toxicity. JAMA Netw Open. Published 2 June 2025. doi:10.
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