Respiratory failure & ventilation
Can central venous pressure help identify acute right ventricular dysfunction in mechanically ventilated critically ill patients?
Authors' conclusion
CVP may be a helpful indicator of acute RV dysfunction patients with systemic venous congestion in mechanically ventilated critically ill, but its accuracy is limited. A CVP less than10 mm Hg can almost rule out RV dysfunction with congestion. In contrast, CVP should not be used to identify general RV dysfunction.
Study context
- Population
- Mechanically ventilated critically ill patients with transthoracic echocardiography and central venous pressure (CVP) monitoring
- Participants
- 518 participants
- Comparison
- CVP for identifying acute right ventricular (RV) dysfunction
- Normal RV functionn = 301reference
- Isolated RV dysfunctionn = 164
- RV dysfunction with congestionn = 53
- Outcome
- Discriminative ability of CVP for identifying RV dysfunction with congestion
Performance
As reported in the abstract
CVP for RV dysfunction with congestion
| Test or model | AUC | Optimal cutoff | Sensitivity | Specificity | NPV | PPV | Gray zone |
|---|---|---|---|---|---|---|---|
| CVP | 0.839 (95% CI 0.795-0.883; p < 0.001) | 10 mm Hg | 79.2% | 69.4% | 96.7% | 22.8% | 9 mm Hg to 12 mm Hg; 95 patients (18.3%) |
CVP
AUC0.839 (95% CI 0.795-0.883; p < 0.001)
Optimal cutoff10 mm Hg
Sensitivity79.2%
Specificity69.4%
NPV96.7%
PPV22.8%
Gray zone9 mm Hg to 12 mm Hg; 95 patients (18.3%)
Further findings
| Outcome | Values |
|---|---|
| CVP for all RV dysfunction | CVP AUC 0.616 (95% CI 0.567-0.665; p < 0.001) · gray zone 5 mm Hg to 12 mm Hg; 349 patients (67.4%) |
Original publication
Can central venous pressure help identify acute right ventricular dysfunction in mechanically ventilated critically ill patients? Ann Intensive Care. Published 20 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →