Respiratory failure & ventilation
Cardiovascular Subphenotypes in Acute Respiratory Distress Syndrome*
Main finding · 90-day mortality by subphenotypeResult — go to the resultOdds ratio 6.9 95% CI 4.0–11.8Authors' conclusion
LCA of TTE parameters identified four cardiovascular subphenotypes in ARDS that more closely aligned with circulatory failure mechanisms and mortality than current RVD definitions.
Study context
- Population
- ICU patients with acute respiratory distress syndrome (ARDS) who received TTE within 7 days of ARDS onset, University Hospital ICU, Birmingham, UK, April 2016–December 2021single centre
- Participants
- 801 patients
- Exposure
- Four TTE/hemodynamic cardiovascular subphenotypes (latent class analysis (LCA)-derived) vs current right ventricular dysfunction (RVD) definitions for mortality
- Outcome
- 90-day mortality by subphenotype
- Follow-up
- 90 days
Methodological detailssingle-centre, latent class analysis
- Single-centre
- Latent class analysis
Main finding
As reported in the abstract
Odds ratio
6.9
95% CI 4.0–11.8
By group
Class 3
OR 6.9 (95% CI 4.0–11.8)
Observational data: associations, not effects.
Further findings
- Different three-variable models had high diagnostic accuracy in identifying each latent subphenotype
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiovascular Subphenotypes in Acute Respiratory Distress Syndrome*. Crit Care Med. Published 6 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →