Respiratory failure & ventilation

Right ventricle-specific therapies in acute respiratory distress syndrome: a scoping review

Crit CarePublished Scoping review

Authors' conclusion

Given the prevalence of RVD in ARDS and its association with mortality, the dearth of research on this topic is concerning.

Study context

Population
Patients with acute respiratory distress syndrome (ARDS) and right ventricular dysfunction (RVD); studies reporting effects of treatments on right ventricular function
Participants
1,526 patients · 51 studies
Outcome
Interventions and designs of included studies
Methodological details1,430 studies screened; MEDLINE, Embase, CINAHL, Web of Science, Cochrane Central searched; extraction in duplicate
  • 1,430 studies screened; MEDLINE, Embase, CINAHL, Web of Science, Cochrane Central searched; extraction in duplicate

Main finding

As reported in the abstract

Ventilator settings
29.4%
Inhaled medications
33.3%
Extracorporeal life support
13.7%
IV or oral medications
13.7%
Prone positioning
9.8%
Non-randomized experimental studies
53%
Case reports
16%
RCTs
5.9%
Studies conducted with the goal of modifying RV function
27%

Original publication

Right ventricle-specific therapies in acute respiratory distress syndrome: a scoping review. Crit Care. Published 12 March 2023. doi:10.1186/s13054-023-04395-9

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