Cannabinoids and General Anesthetics: Revisiting Molecular Mechanisms of Their Pharmacological Interactions
Study context
- Population
- Surgical patients who are regular cannabis consumers; animal models and humans
Main finding
As reported in the abstract
- Animal studies: some show phytocannabinoids (THC, CBD, CBN) potentiate effects of inhalation and IV anesthetics; others show effects comparable with humans
- Clinical studies and case reports: increased requirements of GABAergic anesthetics (isoflurane, sevoflurane, propofol, midazolam) for adequate anesthesia
- Humans: THC ingestion enhances hypnotic effect of ketamine
- Animal studies: cannabinoids enhance opioid analgesia via endogenous cannabinoid system (ECS)–endogenous opioid system (EOS) synergy at spinal cord and CNS
- Humans: cannabis users have higher postoperative pain scores and increased opioid requirements
Original publication
Cannabinoids and General Anesthetics: Revisiting Molecular Mechanisms of Their Pharmacological Interactions. Anesth Analg. Published 6 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →