Neuronal Cell Death Modalities and Protective Mechanisms Induced By Sevoflurane: A Narrative Review
Authors' conclusion
Here, we highlight the importance of distinct cell death modalities in sevoflurane-induced neurotoxicity in populations at risk and propose several strategies for minimizing these effects.
Study context
- Population
- Developing and aged brains exposed to sevoflurane (animal and clinical studies)
- Outcome
- Cell death modalities in sevoflurane-induced neurotoxicity
Main finding
As reported in the abstract
- Major cell death modalities described on sevoflurane exposure: apoptosis, ferroptosis, necroptosis, pyroptosis; also mitochondrial dysfunction and oxidative stress
- Sevoflurane limits cell death in distinct cells such as cardiomyocytes and under conditions such as anesthesia preconditioning
Original publication
Neuronal Cell Death Modalities and Protective Mechanisms Induced By Sevoflurane: A Narrative Review. Anesth Analg. Published 6 May 2026. doi:10.
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