Cannabis Use and Inhalational Anesthesia Administration in Older Adults: A Propensity-matched Retrospective Cohort Study
Main findingResult — go to the resultMean difference 0.04 95% CI 0.01–0.06Authors' conclusion
Cannabis use was associated with administering statistically significantly higher inhalational anesthetic minimum alveolar concentration equivalents in older adults, but the clinical significance of this difference is unclear.
Study context
- Population
- Surgical patients 65 yr or older, University of Florida Health System, 2018–2020propensity-matched
- Participants
- 1,340 patients
- Exposure
- Cannabis use vs no cannabis use within 60 days of surgery
- Cannabis usersn = 268
- Nonusersn = 1,072reference
- Outcome
- Intraoperative time-weighted average of isoflurane or sevoflurane MAC equivalents at 1-min resolution
Methodological detailspropensity-score matched (4:1)
- Propensity-score matched (4:1)
Main finding
As reported in the abstract
Mean difference
0.04
95% CI 0.01–0.06
P = 0.020
By group
Cannabis users
0.58
mean · SD 0.23
Nonusers
0.54
mean · SD 0.22
Cannabis users vs Nonusers
mean difference 0.04 (95% CI 0.01–0.06); P = 0.020
Observational data: associations, not effects.
Original publication
Cannabis Use and Inhalational Anesthesia Administration in Older Adults: A Propensity-matched Retrospective Cohort Study. Anesthesiology. Published 9 July 2024. doi:10.
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