Dementia risk amongst older adults with hip fracture receiving general anaesthesia or regional anaesthesia: a propensity-score-matched population-based cohort study
Authors' conclusion
The incidence rate ratios of dementia amongst older adults undergoing hip fracture surgery were higher for those receiving general anaesthesia than for those receiving regional anaesthesia, with inhalational anaesthesia associated with a higher incidence rate ratio for dementia than total intravenous anaesthesia (TIVA).
Study context
- Population
- Patients aged ≥65 yr receiving elective hip fracture surgery, 2002–2019, Taiwanpropensity-score matched
- Participants
- 268,014 patients
- Exposure
- Inhalational GA vs total intravenous anaesthesia-general anaesthesia (TIVA-GA) vs regional anaesthesia (RA) for hip fracture surgery
- Inhalational GAn = 89,338
- TIVA-GAn = 89,338
- RAn = 89,338reference
- Outcome
- Dementia incidence
Methodological detailspropensity-score matched, 1:1 matching, Taiwanese National Health Insurance Research Database
- Propensity-score matched
- 1:1 matching
- Taiwanese National Health Insurance Research Database
Main finding
As reported in the abstract
Dementia incidence rate
Incidence rate ratio (95% CI)
Inhalational GA vs TIVA-GA
1.19(1.14–1.25)
Inhalational GA vs RA
1.51(1.15–1.66)
TIVA-GA vs RA
1.28(1.09–1.51)
Observational data: associations, not effects.
Original publication
Dementia risk amongst older adults with hip fracture receiving general anaesthesia or regional anaesthesia: a propensity-score-matched population-based cohort study. Br J Anaesth. Published 31 December 2022. doi:10.
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