General anesthesia is not associated with dementia in older adults with osteoarthritis for hip/knee replacements, a national population-based nested case-control study
Main finding · Odds of dementia, GA vs RAResult — go to the resultOdds ratio 1.11 95% CI 0.73–1.70Authors' conclusion
Neither general anesthesia nor regional anesthesia in hip/knee surgery was associated with dementia. Different numbers and durations of anesthesia exposure showed no significant differences in the odds for dementia.
Study context
- Population
- Patients aged 65 years and above diagnosed with osteoarthritis 2002–2010, Taiwan national health insurance databaseosteoarthritis cohort
- Participants
- 59,817 patients
- Comparison
- GA vs RA during hip/knee replacement surgery
- Dementian = 2,171
- Non-dementian = 4,342reference
- Outcome
- Odds of dementia by exposure to GA vs RA during hip/knee replacement surgery
Methodological detailsnational population-based, 1:2 random matching
- National population-based
- 1:2 random matching
Main finding
Odds of dementia, GA vs RA
Odds ratio
1.11
95% CI 0.73–1.70
GA vs RA
OR 1.11 (95% CI 0.73–1.70)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Odds of dementia by GA duration vs no exposureGA <2 h vs No exposure | 0.91 (0.43–1.92) | |
| Odds of dementia by GA duration vs no exposureGA 2-4 h vs No exposure | 1.21 (0.82–1.79) | |
| Odds of dementia by GA duration vs no exposureGA >4 h vs No exposure | 0.39 (0.15–1.01) | |
| Odds of dementia by RA duration vs no exposureRA <2 h vs No exposure | 1.18 (0.85–1.62) | |
| Odds of dementia by RA duration vs no exposureRA 2-4 h vs No exposure | 0.9 (0.64–1.27) | |
| Odds of dementia by RA duration vs no exposureRA >4 h vs No exposure | 0.55 (0.15–1.96) | |
| Odds of dementia by number of replacement surgeriesTwice vs Once | 0.74 (0.44–1.23) | |
| 0.10.31310Odds ratio (log scale) |
Original publication
General anesthesia is not associated with dementia in older adults with osteoarthritis for hip/knee replacements, a national population-based nested case-control study. J Clin Anesth. Published 27 March 2024. doi:10.
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