Pediatric anesthesia & critical care
Capnodynamic end‐expiratory lung volume assessment in anesthetized healthy children
Authors' conclusion
Capnodynamic noninvasive and continuous end-expiratory lung volume CO2 values assessed during anesthesia in children were in close agreement with previously reported end-expiratory lung volume values generated by alternative methods.
Study context
- Population
- Children with healthy lungs (median age 8 months, range 1–36 months) undergoing GA, examined before start of surgery
- Participants
- 15 children
- Exposure
- PEEP 10 vs baseline PEEP 3 cmH2 O
- Outcome
- Normal values for end-expiratory lung volume CO2 (capnodynamic)
Main finding
As reported in the abstract
End-expiratory lung volume CO2
Baseline PEEP 3
32
95% CI 29–34 · mL kg-1
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| End-expiratory lung volume CO2 response to PEEP changesPEEP 10, 1 min vs Baseline PEEP 3 | PEEP 10, 1 min 39 (95% CI 35–43) mL kg-1 · PEEP 10, 3 min 37 (95% CI 34–41) mL kg-1 · Return to PEEP 3 33 (95% CI 29–37) mL kg-1 | P < 0.0001 |
| End-expiratory lung volume CO2 response to PEEP changesPEEP 10, 3 min vs Baseline PEEP 3 | P = 0.0003 | |
| End-expiratory lung volume CO2 response to PEEP changesReturn to PEEP 3 vs Baseline PEEP 3 | P = 0.72 | |
| Airway dead spacePEEP 10, 1 min vs Baseline PEEP 3 | Baseline PEEP 3 1.1 (95% CI 0.9–1.4) mL kg-1 · PEEP 10, 1 min 1.4 (95% CI 1.1–1.8) mL kg-1 · PEEP 10, 3 min 1.5 (95% CI 1.1–1.8) mL kg-1 · Return to PEEP 3 1.2 (95% CI 0.9–1.4) mL kg-1 | P = 0.003 |
| Airway dead spacePEEP 10, 3 min vs Baseline PEEP 3 | P < 0.0001 | |
| Airway dead spaceReturn to PEEP 3 vs Baseline PEEP 3 | P = 0.08 |
Other volumetric capnography and lung function variables
- No major changes in response to PEEP variations
Original publication
Capnodynamic end‐expiratory lung volume assessment in anesthetized healthy children. Paediatr Anaesth. Published 6 December 2023. doi:10.
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