Carbon dioxide elimination as a guide to venoarterial extracorporeal membrane oxygenation weaning: a prospective observational study
Authors' conclusion
EtCO2 and the VCO2NL ratio may be valuable indicators for predicting successful VA-ECMO weaning. Higher EtCO2 and VCO2NL ratio values are associated with a greater likelihood of successful weaning.
Study context
- Population
- Mechanically ventilated patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) for refractory cardiogenic shock, Anzhen Hospital, January 2023–December 2024562 data points
- Participants
- 91 participants
- Exposure
- EtCO2 and VCO2NL ratio as predictors of successful VA-ECMO weaning
- Outcome
- Predictive performance of EtCO2 and VCO2NL ratio for successful VA-ECMO weaning
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Prediction of successful VA-ECMO weaning
EtCO2
0.84
95% CI 0.79–0.89
AUC (EtCO2 > 34 mmHg)
VCO2NL ratio
0.85
95% CI 0.80–0.89
AUC (VCO2NL ratio > 79%)
OR for successful weaning (95% CI)P value
EtCO2
1.26(1.17–1.37)
P < 0.0001VCO2NL ratio
1.14(1.09–1.21)
P < 0.0001Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Carbon dioxide elimination as a guide to venoarterial extracorporeal membrane oxygenation weaning: a prospective observational study. Ann Intensive Care. Published 14 October 2025. doi:10.
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