Cardiothoracic & vascular anesthesia
Cardiopulmonary Bypass Blood Flow Rates and Major Adverse Kidney Events in Cardiac Surgery: A Propensity Score-adjusted Before–After Study
Main findingResult — go to the resultOdds ratio 0.779 95% CI 0.661–0.919Authors' conclusion
In patients undergoing cardiac surgery, increased CPB-BFR was associated with a decrease in MAKE at 30 days including mortality and renal replacement therapy.
Study context
- Population
- Adults undergoing elective and urgent cardiac surgery without severe chronic renal failure, cardiopulmonary bypass (CPB) duration ≥90 minutes, university hospital
- Participants
- 533 adults
- Exposure
- CPB blood flow rate target >2.4 vs >2.2 L/min/m²
- Low CPB-BFRn = 270reference
- High CPB-BFRn = 263
- Outcome
- MAKE:
- Death
- RRT
- Persistent renal dysfunction
- Follow-up
- 30 days
Methodological detailssingle-centre, propensity score-adjusted
- Single-centre
- Propensity score-adjusted
Main finding
As reported in the abstract
Odds ratio
0.779
95% CI 0.661–0.919
P < 0.001
By group
High CPB-BFR vs low CPB-BFR
OR 0.779 (95% CI 0.661–0.919); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Low CPB-BFR | High CPB-BFR | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| 30-day mortality | 5% | 1% | 0.697 (0.595–0.817) | P = 0.001 | |
| RRT | 4% | 1% | 0.739 (0.604–0.904) | P = 0.016 | |
| 0.512Odds ratio (log scale) |
Original publication
Cardiopulmonary Bypass Blood Flow Rates and Major Adverse Kidney Events in Cardiac Surgery: A Propensity Score-adjusted Before–After Study. J Cardiothorac Vasc Anesth. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →