Hemodynamics, fluids & transfusion
Cardiovascular effects of lactate in healthy adults
Authors' conclusion
In healthy participants, LAC infusion enhanced cardiac function, evidenced by increases in CO, stroke volume, and left ventricular ejection fraction compared with SAL.
Study context
- Population
- Healthy male adultscrossover
- Participants
- 8 adults
- Comparison
- Half-molar lactate vs sodium-matched hypertonic sodium chloride
- Primary endpoint
- CO measured by echocardiography
Methodological detailscrossover, single-blinded, assessor-blinded echocardiography
- Crossover
- Single-blinded
- Assessor-blinded echocardiography
Primary result
As reported in the abstract
CO (echocardiography)
Cardiac output (CO) increased during lactate (LAC) vs SAL infusion
1.0 L/min
95% CI 0.5–1.4 L/minP < 0.001
Further findings
| Outcome | Increase (mmol/L) (95% CI) | P value | |
|---|---|---|---|
| Circulating lactate levels | 1.9 (1.8–2.0) | P < 0.001 | |
| −10123Difference, mmol/L (linear scale) |
Stroke volume
- Significant increase in stroke volume during LAC vs SAL infusion, primarily driving the CO increase
- 11 mL (95% CI 4-17 mL, P = 0.002)
Heart rate
- No significant change in heart rate
Left ventricular ejection fraction
- Left ventricular ejection fraction improved during LAC vs SAL infusion
- 5 percentage points (P < 0.001)
Global longitudinal strain
- Global longitudinal strain improved during LAC vs SAL infusion
- 1.5 percentage points (P < 0.001)
Preload indicators
- Elevated during SAL vs LAC infusion
Afterload (systemic vascular resistance, effective arterial elastance) and MAP
- Afterload significantly decreased with LAC vs SAL; MAP similar
Contractility indicators
- Improved during LAC infusion
Original publication
Cardiovascular effects of lactate in healthy adults. Crit Care. Published 17 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →