Hemodynamics, fluids & transfusion
The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study
Authors' conclusion
In human endotoxaemia, plasma resuscitation reduced leucocyte and neutrophil levels but did not reduce glycocalyx degradation, when compared with equal volume resuscitation with a balanced crystalloid solution.
Study context
- Population
- Healthy male volunteers injected with 2 ng kg-1 lipopolysaccharide (LPS) to induce systemic inflammation
- Participants
- 12 volunteers
- Comparison
- Solvent detergent plasma vs balanced salt solution after LPS
- Primary endpoint
- Plasma syndecan-1 (marker of glycocalyx degradation)
Methodological detailshuman volunteer endotoxaemia model
- Human volunteer endotoxaemia model
Primary result
As reported in the abstract
Plasma syndecan-1 (glycocalyx degradation)
LPS increased syndecan-1 (median increase)
2920-4430 pg ml-1
P<0.05
Further findings
Neutrophils and plasma matrix metalloproteinase-9
- Lower with SDP vs balanced salt solution
Neutrophil extracellular trap formation and inflammation
- Not affected by fluid therapy
Coagulation
- SDP reduced LPS-induced prolonged prothrombin time; no impact on other coagulation biomarkers
Original publication
The effects of balanced crystalloid versus plasma on endothelial injury, systemic inflammation, and coagulation in experimental endotoxaemia: a randomised human volunteer study. Br J Anaesth. Published 18 October 2025. doi:10.
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