Hemodynamics, fluids & transfusion
Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial— The ABC-Sepsis Trial*
Primary result · Recruitment and 30-day mortalityResult — go to the resultAdjusted odds ratio 1.50 95% CI 0.84–2.83Authors' conclusion
Our results suggest it is feasible to recruit critically ill patients to a fluid resuscitation trial in U.K. EDs using 5% HAS as a primary resuscitation fluid. There was lower mortality in the balanced crystalloid arm.
Study context
- Population
- Adults with sepsis and National Early Warning Score 2 ≥5 requiring IV fluids, emergency departments (EDs) of 15 UK National Health Service (NHS) hospitals300 randomized
- Participants
- 301 adults
- Comparison
- 5% human albumin solution (HAS) vs Crystalloid
- Primary endpoint
- Feasibility outcomes: recruitment rate and 30-day mortality
- Follow-up
- 30 days
Methodological detailsfeasibility trial, multicentre, open, parallel-group
- Feasibility trial
- Multicentre
- Open
- Parallel-group
Primary result
Recruitment and 30-day mortality
Adjusted odds ratio
1.50
95% CI 0.84–2.83
Events by treatment group
5% HAS vs Crystalloid
aOR 1.50 (95% CI 0.84–2.83)
As reported in the abstract
- Participants recruited over 12 months
- 301
- Screened
- 1303
- Potentially eligible
- 502
- Receiving the intervention
- greater than 95%
- Median participants per site (range 1-63)
- 19
- Overall 30-day mortality (n = 53)
- 17.9%
Original publication
Albumin Versus Balanced Crystalloid for the Early Resuscitation of Sepsis: An Open Parallel-Group Randomized Feasibility Trial— The ABC-Sepsis Trial*. Crit Care Med. Published 24 June 2024. doi:10.
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