Hemodynamics, fluids & transfusion
Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial
Primary resultResult — go to the resultDifference - 3.8 h 95% CI - 8 to 0.4Authors' conclusion
In patients after cardiac surgery, when compared to a crystalloid-based FBT, 20% albumin FBT was associated with a reduced positive fluid balance but did not significantly reduce the duration of vasopressor therapy.
Study context
- Population
- Cardiac surgery patients deemed to require fluid bolus therapy (FBT) in six intensive care units (ICUs)466 analysed
- Participants
- 480 patients
- Comparison
- FBT with 20% albumin vs crystalloid FBT
- Primary endpoint
- Cumulative duration of vasopressor therapy
Methodological detailsmulticentre, parallel-group, open-label
- Multicentre
- Parallel-group
- Open-label
Primary result
As reported in the abstract
Difference
- 3.8 h
95% CI - 8 to 0.4
P = 0.08
By group
Secondary outcomes
| Outcome | Mean difference (mL) (95% CI) |
|---|---|
| Day one fluid balance | - 701 (- 872 to - 530) |
Original publication
Twenty percent human albumin solution fluid bolus administration therapy in patients after cardiac surgery-II: a multicentre randomised controlled trial. Intensive Care Med. Published 2 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →