Cardiothoracic & vascular anesthesia
The Renal Effect of 20% Human Albumin Solution Fluid Bolus Therapy in Patients After Cardiac Surgery. A Secondary Analysis of the HAS FLAIR II Randomized Clinical Trial
Primary result · AKIResult — go to the resultOdds ratio 1.13 95% CI 0.73–1.76Authors' conclusion
FBT with 20% albumin compared with crystalloid-based regimen did not reduce the occurrence of AKI in patients after cardiac surgery. However, it reduced the severity and duration of stages 2 and 3 AKI.
Study context
- Population
- Patients requiring clinician-determined fluid bolus therapy (FBT) after cardiac surgery with CPB, six ICUsmodified ITT population
- Participants
- 452 patients
- Comparison
- FBT with 20% albumin vs crystalloid FBT
- 20% albuminn = 224
- Crystalloidn = 228reference
Methodological detailsmulticentre, parallel-group, open-label
- Multicentre
- Parallel-group
- Open-label
Primary result
AKI
Odds ratio
1.13
95% CI 0.73–1.76
Events by treatment group
20% albumin vs Crystalloid
OR 1.13 (95% CI 0.73–1.76)
As reported in the abstract
Further findings
Median, µmol/L
| Outcome | 20% albumin | Crystalloid | Difference (µmol/L) (95% CI) | P value | |
|---|---|---|---|---|---|
| TWA creatinine (stages 2 and 3 AKI subgroup) | 144 (IQR 109–162) | 254 (IQR 182–294) | −105 (−170 to −41) | P = 0.003 | |
| −200−1000100Difference, µmol/L (linear scale) |
| Outcome | Estimate | P value |
|---|---|---|
| Peak serum creatinine (stages 2 and 3 AKI subgroup) | −110 µmol/L (CI −189 to −32) | P = 0.01 |
Time-weighted average (TWA) creatinine by preoperative serum albumin (subgroup)
- Reduced TWA creatinine with 20% albumin, low preoperative serum albumin
- P = 0.04
- Reduced TWA creatinine with 20% albumin, normal preoperative serum albumin
- P < 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Renal Effect of 20% Human Albumin Solution Fluid Bolus Therapy in Patients After Cardiac Surgery. A Secondary Analysis of the HAS FLAIR II Randomized Clinical Trial. J Cardiothorac Vasc Anesth. Published 3 January 2025. doi:10.
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